What is adapalene used for?

Adapalene is commonly used to treat acne vulgaris on your skin.

Adapalene may also be used for other conditions as determined by your healthcare provider.

How is adapalene supplied (dosage forms)?

Adapalene is available as Differin and generic adapalene in the following dosage forms that are applied to the skin.

• 0.1% topical cream
• 0.1% topical gel
• 0.3% topical gel
• 0.1% topical lotion
• 0.1% topical solution

Side Effects

The most common side effects of adapalene are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

• Skin irritation such as redness, itching, burning, or stinging
• Dry, flaky skin

There may be other side effects of adapalene that are not listed here.

What are the serious side effects of adapalene?

While less common, the most serious side effects of adapalene are described below, along with what to do if they happen.

Severe Allergic Reactions. Adapalene can cause allergic reactions, which can be serious. Stop using adapalene and get help right away if you have any of the following symptoms of a serious allergic reaction.

Breathing problems or wheezing

Racing heart

Fever or general ill feeling

Swollen lymph nodes

Swelling of the face, lips, mouth, tongue, or throat

Trouble swallowing or throat tightness

Itching, skin rash, or pale red bumps on the skin called hives

Nausea or vomiting

Dizziness, feeling lightheaded, or fainting

Stomach cramps

Joint pain

Skin Reaction. Skin reactions are usually not severe, and decrease with continued use of adapalene. You may need to use moisturizers, decrease how often you apply adapalene, or stop using it if you have trouble tolerating treatment. 

Who should not use adapalene?

Allergies to Ingredients. People who are allergic to adapalene, Differin, or any of the ingredients in the specific product dispensed should not use adapalene.

Your pharmacist can tell you all the ingredients in the specific adapalene products they stock.

What should I know about adapalene before using it?

Do not use adapalene unless it has been prescribed to you by a healthcare provider. Use it as prescribed.

Do not share adapalene with other people, even if they have the same condition as you. It may harm them.

Keep adapalene out of the reach of children.

Disclaimer: Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.