Uses

Tobramycin+dexamethasone is a topical antibiotic indicated in the treatment of external infections of the Eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of Tobramycin+dexamethasone. Clinical studies have shown tobramycin to be safe and effective for use in children.

Dosage for Tobramycin+dexamethasone

In mild to moderate disease, instill 1 or 2 drops into the affected eye every 4 hours. In severe infections, instill 2 drops into the eye hourly until improvement, following which treatment should be reduced prior to discontinuation.

HOW SUPPLIED

Tobramycin+dexamethasone is supplied as a 5 mL sterile solution, packaged in a 8 mL low density polyethylene white bottle and natural dispensing plug and white polypropylene closure as follows:

5 mL containing tobramycin 0.3% (3 mg/mL)

Side Effects

The most frequent adverse reactions toTobramycin+dexamethasone(tobramycin ophthalmic solution) 0.3% are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than three of 100 patients treated with Tobramycin+dexamethasone.

Postmarketing Experience

Additional adverse reactions identified from post-marketing use include anaphylactic reaction, Stevens-Johnson syndrome, and erythema multiforme.

The following additional adverse reactions have been reported with systemic aminoglycosides: Neurotoxicity, ototoxicity and nephrotoxicity have occurred in patients receiving systemic aminoglycoside therapy. Aminoglycosides may aggravate muscle weakness in patients with known or suspected neuromuscular disorders, such as myasthenia gravis or Parkinson’s disease, because of their potential effect on neuromuscular function.

Warnings

FOR TOPICAL OPHTHALMIC USE. NOT FOR INJECTION INTO THE Eye. Sensitivity to topically applied aminoglycosides may occur in some patients. Severity of hypersensitivity reactions may vary from local effects to generalized reactions such as erythema, itching, urticaria, skin rash, anaphylaxis, anaphylactoid reactions, or bullous reactions. If a sensitivity reaction toTobramycin+dexamethasone (tobramycin ophthalmic solution) 0.3% occurs, discontinue use.

Disclaimer: Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.